منابع مشابه
Kinetochores feel the pull
S uzuki et al. (1) take a close look at how kinetochores change shape when spindle microtubules tug on them. They fi nd that only part of the kinetochore stretches and identify a protein that might confer this ability. Kinetochores, which hook the fi bers of the mitotic spindle to chromosomes, are more than passive fasteners. Fashioned from more than 100 proteins, the structures are dynamic and...
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Fungal pores feel the pull S teinberg et al. report that fungi use motor proteins to distribute their nuclear pores around the nuclear envelope. In animal cells, the nuclear lamina holds the nuclear pores in place, ensuring that they are evenly spaced. The lamina prevents nuclear pores from clustering, promoting import of cargoes through the pores and helping to organize the chromosomes, which ...
متن کاملKinetochores
Not to be confused with1⁄4 centrosomes. But it’s OK to confuse them with centromeres. The centromere is the chromosomal domain where the kinetochore is assembled. Genetically speaking, the centromere is the locus necessary to segregate chromosomes. In many species, the centromere is also defined cytologically as the primary constriction visible on condensed chromosomes (the intersection point o...
متن کاملKinetochores: NDC80 Toes the Line
Kinetochore-associated NDC80 complexes serve as the primary binding site for the plus-ends of spindle microtubules in mitosis. A recent study proposes a novel mechanism for regulating kinetochore-microtubule binding involving NDC80 complex oligomerization, which could be mediated by Aurora B kinase.
متن کاملKinetochores: Orchestrating the Chromosomal Minuet
When it comes to microtubules, kinetochores leave nothing to chance. Recent studies have provided insight into an amazingly choreographed dance between the proteins in the kinetochore and their substrate and power source--the microtubule.
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2011
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1931if